Make room, Genocea and Rational Vaccines. There may be a new kid on the block.
A new study describes a trivalent vaccine—containing different strains — called HSV-2 gC2/gD2/gE2. HSV-2 refers to the herpes strain that causes genital herpes (1), and gC2, gD2, and gE2 are glycoproteins—proteins that are bound to sugars—that have different functions. The gD2 protein helps block the entry of the virus into the cell, while gC2 and gE2 help the virus evade the immune system.
This means that the vaccine produces antibodies that target two different mechanisms that help HSV-2 cause infection.
The degree of protection of the new vaccine, as well as the...