nanotechnology

Part of the global effort to discover new antibiotics involves inventing new techniques to analyze the ones we already have. The idea is that the more we learn about how antimicrobials work at the molecular level, the easier it will be to find or synthesize novel ones.

One way to learn about how antibiotics work is to visualize their accumulation within bacterial cells. But this is no easy feat. Several imaging techniques already exist, such as monitoring fluorescence or tracking molecules using radioactive labels, but these methods suffer from various drawbacks. So, a team of researchers from Penn State University and the pharmaceutical and biotechnology giant Novartis set about inventing a new technique.

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Special bacteria-killing surfaces constitute a highly active area of research and development.

Strategies to construct them vary widely. One group has infused a slippery surface with molecules that disrupt bacterial communication. Others have shown that silver nanoparticle coatings can destroy bacteria. Yet another group used black silicon to create a surface that resembled a tiny "bed of nails" (nanopillars), which physically rip bacteria apart.

That latter example, which ...

Black silicon. (Credit: Sedao (2009)/Wikimedia Commons) Black silicon. (Credit: Sedao (2009)/Wikimedia Commons)

Surfaces that discourage bacterial growth are in high demand, particularly as more patients require catheters and implants. Last month, we reported on a new anti-bacterial surface that incorporates molecular compounds that can block bacteria's ability to communicate and form biofilms, which...