C. diff

Clostidioides difficile causes diarrhea that can be severe, and can lead to toxic megacolon, sepsis and death.  It occurs in about 58 per 100,00 hospital admissions in the healthcare setting and an additional 63 per 100,000 per
The study published in Nature Medicine looked at C. diff. infections, the most common cause of hospital-related diarrhea, and a significant cause of patient morbidity and mortality.
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