Every Picture Tells a Story: Smoking vs. Vaping       

The study looked at the expression of genes among exclusive users of e-cigarettes, smokers including dual users, and controls without any tobacco use. The dual users may muddy the waters, but you can apply as much salt as you will.

• Both conventional and e-cigarette users showed differential gene expression than controls
• Smokers had nearly 7.5 fold more changes in both up and down-regulation of genes than those using e-cigarettes.
• Our mitochondria have 37 genes; e-cigarette users have alterations in 11 of those genes, smokers 32.
• The overlap suggests that both products contain the same “stimulus” to these differential gene expressions, although the inclusion of dual users, as I mentioned, makes this finding less certain.
• Signals to macrophages, part of our immune response, were the most impacted in vapers, mitochondrial energetics that power our lives, the most impacted in smokers.
• For 80% of the differential gene expressions in vapers, it was dose-dependent, for smokers roughly a third.

“Lastly, we have shown accentuated transcriptomic effects in smokers relative to vapers, suggesting that smoking has greater and more pronounced adverse effects than vaping on biological systems.”

Smoking is bad, vaping a bit better, especially if it is the pathway to quitting. Never inhaling tobacco either from combustion or vaporization is best.

Source: A novel role for vaping in mitochondrial gene dysregulation and inflammation fundamental to disease development Scientific Reports DOI: 10.1038/s41598-021-01965-1