p-values

P-values are the statistical coin of the realm in determining the significance, at least statistically, of a randomized controlled study – our gold standard. But might we apply a different metric to determine whether an impact is found?

Randomized clinical trials remain the “gold-standard” evidence in making standards, that is the creation of clinical guidelines. They are a form of best practice creating a “floor” for the care patients receive.

Science and medicine often deal with issues that are about finding "the needle in the haystack." We might get a better handle on p-values and science's “reproducibility” problem by considering, metaphorically, those haystacks and needles