Recently, Newsday's David Olson wrote about opioids in an honest way not often seen in mainstream media. He emphasized the harm caused by the “overcorrection of the pendulum” – the shortage of medically legitimate opioids caused by ill-advised restrictions on prescribing. He gives personal accounts of practitioners, pharmacists, and patients struggling to navigate the unforgiving terrain of new laws and policies. Thumbs up to Mr. Olson for this important article.
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Masks were once confined to those celebrating Halloween or as historical notes about historic plagues. But they returned to command our awareness in the Age of COVID. There are differences of opinion on how efficacious they are: the overall benefit versus how much damage they might have done. A new study speaks to their physiologic harms.
“As the field of transgender health care has transitioned from pathologizing patients to a gender-affirming and patient-centered model and from an understanding of gender as binary to a fuller picture of gender as a spectrum, its associated diagnoses have similarly evolved.” An article in JAMA’s newest spinoff, Journal of Ethics, tries to explore the benefits and problems of a medical diagnosis.
“Humans are taking colossal risks with the future of civilization and everything that lives on Earth.” So begins a report in Nature attempting to quantify Safe and Just Earth boundaries. The findings “are meant as a transparent proposal for further debate and refinement by scholars and wider society.” I took them at their word; let’s consider and then debate their proposals.
Congestion pricing
Visually literacy requires us to go slow
A fork in the fertilizer path
African American English
The opioid crisis is fueled by fentanyl, largely a direct product or precursor manufactured in China. It's a rocket-fuel inversion of the Opium Wars, when Britain smuggled illegal opium into China.
Hands began wringing about global warming and subsequent climate change in the 1980s, and those predictions are now being seen. It’s not rocket science; temperature will increase when heat is pumped into a system limited by greenhouse gases. Electric power generation has been the largest source of heat-trapping gases, and the emerging popularity of electric vehicles promises to increase that share. What exactly are the costs and characteristics of electric generating systems?
Melatonin is a neurohormone that the body uses to regulate sleep. It's sold as a dietary supplement without a prescription. As the CDC states, in "2020, melatonin became the most frequently ingested substance among children reported to national poison control centers.”
The EPA’s Integrated Risk Information System (IRIS) was founded in 1985 to assure scientific integrity and present intra-Agency consensus on health effects information on environmental chemicals. It is an excellent example of how a government agency can misuse a well-intentioned idea to meet a political agenda resulting in flawed public policy decisions with significant implications.
The use of dicamba, an herbicide, has become an extremely contentious issue in some farm states. It has been accused of “tearing apart the fabric of rural life.” The issues surrounding dicamba present a fascinating study on modern agriculture and problems that arise when technological advances impact farming choices and basic livelihood.
Sepsis, an overwhelming infection, remains among hospitals’ most difficult conditions to identify and treat. Algorithms within electronic medical records have been developed to help clinicians. So how is this real-world A.I. of medicine working out? Just a bit better than a coin toss.
Our drug laws are almost supernaturally stupid. Part of this, aside from that they're largely made by morons, is the lack of knowledge of even basic chemistry, which could, at least, introduce a little sanity to the process. Here's a bit.
"... [I]nfluenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other 'common cold' viruses ... have not to date been effectively controlled by licensed or experimental vaccines." So wrote Dr. Tony Fauci, former head of the National Institute of Allergy and Infectious Diseases. What can policymakers learn from this controversial analysis? California is poised to ban five commonly used chemicals under the guise of protecting children. There's no science to justify the legislation.
Lost in the debate over how Medicare will negotiate drug prices, there's a concern by federal agencies about a metric used in determining a drug’s value. It's known as the Quality-Adjusted Life Year. There's bipartisan agreement in not using the term QALY, and “not even Medicare officials have signaled they want to use that approach.” What exactly are they talking about?
Former President Trump said, “we have learned to live with it [COVID-19], just like we are learning to live with Covid, in most populations far less lethal!!!” before he recanted that statement with Bob Woodward, saying he knew it was "more deadly than even your strenuous flu." The morbidity and mortality of COVID have indeed changed over time; a recent study helps define whether COVID is becoming a new seasonal influenza.
The mind-body problem is fake science
Zombie pathogens have taken over my brain
There is more to figs than the Newton
Superstition, Enthusiasm, and Politics
Kimchi, initially a household staple of Korea, has increasingly found its complex flavors of vegetables, garlic, ginger, and fish sauce being accepted as a global star. Long before refrigeration, fermented foods were a winter staple. A new study looks at the physics underlying the of making Kimchi.
The EPA recently completed a draft health assessment on Chromium-VI that is causing controversy in the scientific community because it concludes that Chromium-VI is likely to cause cancer through drinking water. This conclusion is at odds with EPA’s previous assessments, much of the scientific literature, and assessments by other countries, including Canada.
Johnson & Johnson is working on a drug to repair liver damage caused by Tylenol, which has made the company billions since it was launched in 1955. Isn't this a bit like having a dentist's office in the back of a candy store?
Traditionalism, a synonym for conservatism, is defined as “the tendency to embrace what are perceived to be the longstanding norms and values of one’s group, while rejecting changes to them.” During COVID, much of the writing on human behavior revolved around the actions of the conservatives vs. liberals. An anthropologic study looks at the role of traditionalism during COVID more globally.
The FDA is responsible for the approval of medications in the U.S. Many similar agencies are doing the same work in other countries. But unlike the U.S. – where cost is not a consideration – several countries including the UK, Canada, and Australia, apply a Health Technology Assessment to consider a new medication’s clinical and economic cost and benefits. A recent study shows they disagree with the FDA’s decision about 20% of the time.
It's a commonly held belief that a full moon brings out the crazies and the craziness. The word "lunatic" – derived from the combination of "luna," or moon, and "atic," meaning “of the kind of” – was first mentioned in a fourth-century Bible. A new study looks at the influence of the moon and some circadian genes on the incidence of suicide.
A not-so-recent paper estimated that for every £ spent on cardiovascular research, there was a continuing 9% savings in health costs 17 years later. If the time from the research bench to the bedside was reduced to 10 years, those continuing savings rose to 13%. Why does it take so long to translate medical science into medical care?
Adderall, one of the primary drugs to treat ADHD, has been in the news lately because of a shortage. But there are a number of different ADHD drugs that contain amphetamine – the active ingredient in Adderall. Perhaps this will help clarify what's going on.
No matter how you slice it "Jamaican vomiting sickness" is something you want to avoid. You can do so by not eating the ackee fruit, a staple of that Caribbean nation – or at least waiting until it's ripe. Here's a lesson about metabolic toxicity wrapped in a mini-travelogue.
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